FAM151A

Across TCGA patient cohorts, FAM151A mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM151A-associated genes across cancer lineages are MEK1, MSH2, and PCNA. Each is linked with FAM151A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM151A-to-partner and partner-to-FAM151A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by FAM151A-low versus FAM151A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM151A→partner) and Y-score (partner→FAM151A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.469	+2.938	<.001	<.001	3	2
UCEC	MSH2 →	-0.221	-2.781	.005	.003	3	2
UCEC	PCNA →	+0.152	+1.415	.043	.043	3	2
UCEC	Caspase-7-cleavedD198 →	+0.518	+1.505	.011	.034	3	2
UCEC	EGFR_pY1068 →	-0.238	-2.115	.006	.017	3	1
UCEC	eIF4E →	+0.173	+2.070	.018	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by FAM151A expression — UCEC

Explore this box plot interactively →