FAM149B1

Across TCGA cell cohorts, FAM149B1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM149B1-associated genes across cancer lineages are IL3, PRAMEF10, and PRAMEF17. Each is linked with FAM149B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM149B1-to-partner and partner-to-FAM149B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by FAM149B1-low versus FAM149B1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM149B1→partner) and Y-score (partner→FAM149B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	1
LARGE_INTESTINE	ACER1 →	+0.090	+4.145	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

IL3 by FAM149B1 expression — LUNG_SCLC

Explore this box plot interactively →