FAM13A

Across TCGA pan-cancer cohorts, FAM13A mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM13A’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where FAM13A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FAM13A is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

PDAC, LUAD, and CCRCC are the cancer types where FAM13A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM13A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−1.498	<.001	9	view →
LUAD	Female	II,III,IV	+0.573	<.001	9	view →
CCRCC	Male	All	+0.571	<.001	9	view →
HNSC	All	All	−0.766	.013	5	view →
LSCC	All	All	−0.124	.030	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FAM13A–PDAC

Open the PDAC breakdown →