FAM138A

Across TCGA pan-cancer cohorts, FAM138A RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated FAM138A data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher FAM138A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM138A expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

ESCA, LUSC, and MESO are the cancer types where FAM138A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Tertile	All	0.827	0.281	.002	105	view →
LUSC	OS	Tertile	II,III,IV	0.318	0.748	<.001	90	view →
MESO	DFS	Tertile	All	0.095	0.369	.004	54	view →
LGG	OS	Tertile	All	0.739	0.903	<.001	36	view →
KIRC	DFS	Tertile	IV	0.224	0.532	.041	18	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
PAAD	OS	Tertile	All	0.138	0.590	<.001	18	view →
SARC	OS	Tertile	All	0.536	0.841	.001	15	view →
THYM	DFS	Tertile	II,III,IV	0.083	0.881	<.001	12	view →
STAD	DFS	Tertile	All	0.263	0.548	.043	9	view →
ACC	DFS	Tertile	III,IV	0.057	0.457	.040	9	view →
HNSC	DFS	Tertile	II,III,IV	0.504	0.300	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

FAM138A–ESCA (DFS)

Open the ESCA breakdown →