FAM136A

Across TCGA pan-cancer cohorts, FAM136A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM136A data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FAM136A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM136A expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where FAM136A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.913	.014	42	view →
CCRCC	DFS	Quartile	All	0.410	1.000	.004	38	view →
LSCC	OS	Median	II,III,IV	0.963	0.605	.002	20	view →
LUAD	DFS	Median	III,IV	0.996	0.485	.001	15	view →
PDAC	DFS	Median	III,IV	0.230	0.480	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM136A–COAD (DFS)

Open the COAD breakdown →