FAM135B

Across TCGA pan-cancer cohorts, FAM135B Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated FAM135B data layer compared with 21 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM135B Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM135B expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, DLBC, and LUAD are the cancer types where FAM135B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.861	0.596	<.001	36	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
LUAD	DFS	Median	IV	0.047	0.565	<.001	10	view →
HNSC	DFS	Median	III,IV	0.751	0.318	.021	9	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
LIHC	DFS	Median	All	0.096	0.553	.030	6	view →
PRAD	DFS	Median	All	0.810	0.935	.003	6	view →
ESCA	DFS	Median	III,IV	0.218	0.461	.022	6	view →
SKCM	DFS	Median	II,III,IV	0.784	0.634	.012	5	view →
SCLC	DFS	Median	All	0.108	0.306	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

FAM135B–UCEC (DFS)

Open the UCEC breakdown →