FAM135A

Across TCGA pan-cancer cohorts, FAM135A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FAM135A data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FAM135A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FAM135A expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where FAM135A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.837	0.271	.021	12	view →
LUAD	DFS	Median	All	0.831	0.941	.004	5	view →
PDAC	DFS	Tertile	II,III,IV	0.745	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FAM135A–CCRCC (OS)

Open the CCRCC breakdown →