FAM135A

Across TCGA patient cohorts, FAM135A mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM135A-associated genes across cancer lineages are RBM15, ACC1, and eEF2. Each is linked with FAM135A in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM135A-to-partner and partner-to-FAM135A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBM15 grouped by FAM135A-low versus FAM135A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM135A→partner) and Y-score (partner→FAM135A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RBM15 →	+0.452	+2.824	.018	.036	3	2
SKCM	ACC1 →	+0.404	+3.321	.012	.010	3	2
UCEC	eEF2 →	+0.199	+0.874	.029	.036	3	2
UCEC	ERK2 →	+0.134	+1.263	.006	.002	3	2
UCEC	MEK1 →	+0.334	+1.547	<.001	<.001	3	2
UCEC	Tuberin →	+0.169	+1.222	.014	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

RBM15 by FAM135A expression — LUAD

Explore this box plot interactively →