FAM133EP

Across TCGA pan-cancer cohorts, FAM133EP RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of FAM133EP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM133EP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM133EP is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KICH, and CHOL are the cancer types where FAM133EP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM133EP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.053	.005	7	view →
KICH	All	All	−0.131	<.001	5	view →
CHOL	All	All	+0.185	.005	4	view →
LUAD	All	IV	+0.175	.007	2	view →
BRCA	Female	All	+0.115	.035	2	view →
LUSC	Male	All	+0.074	.032	1	view →
KIRC	All	All	+0.055	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

FAM133EP–HNSC

Open the HNSC breakdown →