FAM133DP

Across TCGA pan-cancer cohorts, FAM133DP RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated FAM133DP data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher FAM133DP RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM133DP expression acts as an unfavorable survival marker, although some lineages such as SKCM and MESO show a favorable association.

SKCM, DLBC, and LIHC are the cancer types where FAM133DP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	III,IV	0.868	0.722	.001	50	view →
DLBC	DFS	Tertile	All	0.247	0.858	.001	48	view →
LIHC	DFS	Median	All	0.289	0.566	<.001	33	view →
MESO	OS	Median	III,IV	0.808	0.344	.003	21	view →
BRCA	DFS	Median	III,IV	0.616	0.328	<.001	18	view →
KIRC	DFS	Median	All	0.746	0.477	.001	18	view →
UVM	OS	Tertile	III,IV	0.527	0.748	.033	18	view →
SARC	DFS	Tertile	All	0.444	0.620	.004	18	view →
THCA	OS	Median	All	1.000	0.853	.021	15	view →
KICH	OS	Median	II,III,IV	0.600	1.000	.027	11	view →
STAD	OS	Median	III,IV	0.695	0.573	.028	11	view →
ACC	DFS	Tertile	III,IV	0.545	0.088	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

FAM133DP–SKCM (OS)

Open the SKCM breakdown →