FAM131B

Across TCGA patient cohorts, FAM131B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM131B-associated genes across cancer lineages are 14-3-3_beta, ERK2, and FOXO3a. Each is linked with FAM131B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM131B-to-partner and partner-to-FAM131B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FAM131B-low versus FAM131B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM131B→partner) and Y-score (partner→FAM131B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.117	-2.558	.002	.010	3	1
UCEC	ERK2 →	+0.218	+3.584	.003	.002	3	1
UCEC	FOXO3a →	-0.123	-3.877	.001	<.001	3	1
UCEC	Mre11 →	-0.115	-1.584	<.001	.036	3	1
UCEC	p27_pT157 →	-0.063	-2.661	.005	.006	3	1
UCEC	p62 Lck ligand →	+0.263	+2.331	.039	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by FAM131B expression — UCEC

Explore this box plot interactively →