FAM131A

Across TCGA patient cohorts, FAM131A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM131A-associated genes across cancer lineages are eIF4E, Ku80, and Notch1. Each is linked with FAM131A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM131A-to-partner and partner-to-FAM131A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FAM131A-low versus FAM131A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM131A→partner) and Y-score (partner→FAM131A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.228	+2.000	.016	.032	2	2
UCEC	Ku80 →	+0.243	+2.013	.022	.018	3	1
UCEC	Notch1 →	+0.146	+2.817	.021	.036	3	1
UCEC	PDCD4 →	-0.704	-3.169	<.001	.018	3	1
UCEC	Rad50 →	-0.225	-2.000	.040	.032	3	1
UCEC	STAT3_pY705 →	-0.486	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eIF4E by FAM131A expression — UCEC

Explore this box plot interactively →