FAM126A

Across TCGA patient cohorts, FAM126A mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM126A-associated genes across cancer lineages are FASN, INPP4B, and Shc_pY317. Each is linked with FAM126A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM126A-to-partner and partner-to-FAM126A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by FAM126A-low versus FAM126A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM126A→partner) and Y-score (partner→FAM126A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.365	+2.000	.018	.030	3	2
UCEC	INPP4B →	-0.274	-2.000	.030	.030	3	2
UCEC	Shc_pY317 →	-0.178	-2.000	.002	.010	3	2
UCEC	ATM →	-0.542	-1.584	.002	.036	3	2
UCEC	EGFR_pY1068 →	-0.284	-3.459	.003	.005	3	1
UCEC	A-Raf_pS299 →	-0.115	-2.000	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

FASN by FAM126A expression — UCEC

Explore this box plot interactively →