FAM124B

Across TCGA patient cohorts, FAM124B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM124B-associated genes across cancer lineages are Myosin-IIa_pS1943, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with FAM124B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM124B-to-partner and partner-to-FAM124B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by FAM124B-low versus FAM124B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM124B→partner) and Y-score (partner→FAM124B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.217	+2.713	.020	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.567	+2.189	.034	.034	3	2
UCEC	c-Met_pY1235 →	+0.067	+2.000	.045	.032	3	2
UCEC	EGFR_pY1068 →	-0.250	-2.700	.027	.006	3	1
UCEC	FASN →	+0.509	+3.000	.004	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.204	-2.687	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Myosin-IIa_pS1943 by FAM124B expression — UCEC

Explore this box plot interactively →