FAM124B

Across TCGA cell cohorts, FAM124B mutation is significantly associated with the mutation status of many other genes, with 5,232 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM124B-associated genes across cancer lineages are SH3BP1, ASH1L, and PTCH2. Each is linked with FAM124B in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM124B-to-partner and partner-to-FAM124B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3BP1 grouped by FAM124B-low versus FAM124B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM124B→partner) and Y-score (partner→FAM124B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SH3BP1 →	+5.415	+5.415	.004	.004	1	4
LARGE_INTESTINE	ASH1L →	+1.819	+2.392	.003	.003	1	4
LARGE_INTESTINE	PTCH2 →	+1.578	+2.185	.007	.007	1	4
OVARY	NFATC1 →	+5.415	+5.415	.004	.004	1	4
LUNG_NSCLC_LUAD	SNRNP200 →	+4.000	+4.303	.001	.001	1	4
LUNG_NSCLC_LUAD	LTBP3 →	+5.000	+4.187	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,232 associations by consensus.

SH3BP1 by FAM124B expression — OVARY

Explore this box plot interactively →