FAM124A

Across TCGA patient cohorts, FAM124A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM124A-associated genes across cancer lineages are ERK2, STAT3_pY705, and TIGAR. Each is linked with FAM124A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM124A-to-partner and partner-to-FAM124A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FAM124A-low versus FAM124A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM124A→partner) and Y-score (partner→FAM124A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.178	+2.584	.047	.011	3	2
UCEC	STAT3_pY705 →	-0.397	-2.584	.001	.011	3	2
UCEC	TIGAR →	+0.145	+2.611	.041	.006	3	2
UCEC	Ku80 →	+0.314	+1.887	.004	.031	3	1
UCEC	Notch1 →	+0.202	+2.179	.002	.034	3	1
UCEC	Tuberin →	+0.441	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ERK2 by FAM124A expression — UCEC

Explore this box plot interactively →