FAM124A

Across TCGA cell cohorts, FAM124A mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM124A-associated genes across cancer lineages are rTRAIL, AZD7969, and LCL161. Each is linked with FAM124A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM124A-to-partner and partner-to-FAM124A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rTRAIL grouped by FAM124A-low versus FAM124A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM124A→partner) and Y-score (partner→FAM124A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	rTRAIL →	+0.594	+2.807	.032	.045	3	1
LARGE_INTESTINE	AZD7969 →	+0.507	+2.871	.018	.021	3	1
LARGE_INTESTINE	LCL161 →	+0.503	+2.894	<.001	.016	3	1
LARGE_INTESTINE	GSK2801 →	+0.359	+2.871	.016	.021	3	1
LARGE_INTESTINE	123829 →	+0.555	+2.871	.045	.021	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.414	+2.871	.001	.021	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

rTRAIL by FAM124A expression — LARGE_INTESTINE

Explore this box plot interactively →