FAM122B

Across TCGA patient cohorts, FAM122B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM122B-associated genes across cancer lineages are VHL, ATM, and eEF2. Each is linked with FAM122B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM122B-to-partner and partner-to-FAM122B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by FAM122B-low versus FAM122B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM122B→partner) and Y-score (partner→FAM122B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.818	-2.000	<.001	.009	3	2
UCEC	ATM →	-0.325	-1.362	.042	.037	3	2
UCEC	eEF2 →	+0.315	+2.321	.012	.033	3	1
UCEC	EGFR_pY1068 →	-0.310	-2.392	<.001	<.001	3	1
UCEC	eIF4E →	+0.164	+3.183	.027	.009	3	1
UCEC	ACC1 →	+0.332	+1.807	.009	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

VHL by FAM122B expression — UCEC

Explore this box plot interactively →