Across TCGA pan-cancer cohorts, FAM122A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FAM122A data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM122A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM122A expression acts as an unfavorable survival marker, although some lineages such as OV and CCRCC show a favorable association.

HNSC, PDAC, and OV are the cancer types where FAM122A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.915	1.000	.020	15	view →
PDAC	DFS	Tertile	III,IV	0.173	0.834	.038	12	view →
OV	DFS	Median	All	1.000	0.860	.039	8	view →
CCRCC	OS	Tertile	All	0.899	0.769	.027	5	view →
LSCC	DFS	Tertile	III,IV	1.000	0.577	.014	3	view →
GBM	OS	Tertile	All	0.603	0.456	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: FAM122A tumor-vs-normal RNA expression · all FAM122A data types