Across TCGA patient cohorts, FAM122A mutation is significantly associated with the RNA expression of many other genes, with 3,781 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM122A-associated genes across cancer lineages are SRRD, RTCB, and SRSF4. Each is linked with FAM122A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM122A-to-partner and partner-to-FAM122A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM122A→partner) and Y-score (partner→FAM122A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SRRD →	+0.392	+2.362	.002	<.001	3	2
UCEC	RTCB →	+0.509	+2.638	<.001	<.001	3	2
UCEC	SRSF4 →	+0.475	+3.058	<.001	<.001	3	2
UCEC	MFN2 →	+0.486	+2.617	<.001	<.001	3	2
COAD	RTN4IP1 →	+0.516	+3.472	<.001	.002	3	2
UCEC	RPA1 →	+0.591	+2.223	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,781 associations by consensus.

Exploration

FAM122A survival (RNA) · tumor vs normal (RNA) · all FAM122A data types