FAM122A

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, FAM122A mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM122A-associated genes across cancer lineages are NF-kB-p65_pS536, Notch1, and Smad3. Each is linked with FAM122A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM122A-to-partner and partner-to-FAM122A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM122A→partner) and Y-score (partner→FAM122A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECNF-kB-p65_pS536 →-0.386-1.990.020.03032
UCECNotch1 →+0.128+1.502.013.03032
UCECSmad3 →+0.115+2.321.038.03332
UCECASNS →+0.414+1.807.001.02532
UCECCaspase-7-cleavedD198 →+0.765+2.926<.001<.00132
UCECCyclin-E2 →+0.184+1.847.002.00832
Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Exploration