FAM120B

Across TCGA pan-cancer cohorts, FAM120B mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM120B data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM120B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM120B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC and UCEC are the cancer types where FAM120B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.623	0.905	.001	46	view →
UCEC	DFS	Median	All	0.956	0.850	.018	20	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAM120B–HNSC (DFS)

Open the HNSC breakdown →