FAM118A

Across TCGA patient cohorts, FAM118A mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM118A-associated genes across cancer lineages are HER3, Acetyl-a-Tubulin-Lys40, and MEK1. Each is linked with FAM118A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM118A-to-partner and partner-to-FAM118A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by FAM118A-low versus FAM118A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM118A→partner) and Y-score (partner→FAM118A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	+0.471	+2.820	<.001	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.478	+3.331	.043	.005	3	1
UCEC	MEK1 →	+0.498	+3.459	.003	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.282	+2.598	.003	.006	3	1
UCEC	Notch1 →	+0.182	+3.700	.005	.001	3	1
UCEC	p62 Lck ligand →	+0.466	+3.594	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

HER3 by FAM118A expression — UCEC

Explore this box plot interactively →