FAM118A

Across TCGA cell cohorts, FAM118A mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FAM118A-associated genes across cancer lineages are OR1L6, CDX4, and C2orf80. Each is linked with FAM118A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM118A-to-partner and partner-to-FAM118A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by FAM118A-low versus FAM118A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM118A→partner) and Y-score (partner→FAM118A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	2
BONE	CDX4 →	+0.012	+5.129	<.001	<.001	3	1
BONE	C2orf80 →	+0.095	+4.169	<.001	.008	3	1
BONE	PRSS41 →	+0.048	+4.672	<.001	.001	3	1
BONE	ADORA3 →	+0.027	+4.307	<.001	.004	3	1
SKIN	SERPINB12 →	+0.040	+3.920	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR1L6 by FAM118A expression — LARGE_INTESTINE

Explore this box plot interactively →