FAM117B

Across TCGA pan-cancer cohorts, FAM117B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM117B data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM117B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM117B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where FAM117B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.837	0.488	<.001	66	view →
LSCC	OS	Median	All	0.915	0.714	.001	56	view →
PDAC	OS	Median	II,III,IV	0.689	0.365	<.001	37	view →
LUAD	DFS	Tertile	All	0.483	0.832	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FAM117B–HNSC (DFS)

Open the HNSC breakdown →