FAM117B

Across TCGA pan-cancer cohorts, FAM117B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FAM117B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where FAM117B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAM117B is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LSCC, COAD, and LUAD are the cancer types where FAM117B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM117B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.640	<.001	8	view →
COAD	All	All	−1.094	<.001	5	view →
LUAD	Male	All	+0.248	<.001	5	view →
PDAC	All	All	+0.795	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FAM117B–LSCC

Open the LSCC breakdown →