FAM117B

Across TCGA patient cohorts, FAM117B mutation is significantly associated with the RNA expression of many other genes, with 3,299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM117B-associated genes across cancer lineages are FBXO7, SF3A2, and SGTA. Each is linked with FAM117B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM117B-to-partner and partner-to-FAM117B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXO7 grouped by FAM117B-low versus FAM117B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM117B→partner) and Y-score (partner→FAM117B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FBXO7 →	+0.469	+2.158	<.001	<.001	3	2
UCEC	SF3A2 →	+0.369	+2.169	.003	<.001	3	2
UCEC	SGTA →	+0.505	+2.158	<.001	<.001	3	2
UCEC	HPS1 →	+0.382	+2.839	<.001	.001	3	2
UCEC	HPS5 →	+0.446	+1.839	<.001	.002	3	2
UCEC	PFDN1 →	+0.355	+2.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,299 associations by consensus.

FBXO7 by FAM117B expression — UCEC

Explore this box plot interactively →