FAM117B

Across TCGA patient cohorts, FAM117B mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM117B-associated genes across cancer lineages are JNK_pT183_Y185, C-Raf_pS338, and 53BP1. Each is linked with FAM117B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM117B-to-partner and partner-to-FAM117B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by FAM117B-low versus FAM117B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM117B→partner) and Y-score (partner→FAM117B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.143	-1.571	.018	.019	3	2
SKCM	C-Raf_pS338 →	+0.148	+3.000	.040	.036	3	1
SKCM	53BP1 →	-0.560	-3.000	.009	.036	3	1
UCEC	14-3-3_beta →	-0.088	-2.558	.015	.010	3	1
UCEC	eIF4E →	+0.200	+1.925	.008	.005	3	1
UCEC	A-Raf_pS299 →	-0.137	-2.584	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

JNK_pT183_Y185 by FAM117B expression — UCEC

Explore this box plot interactively →