FAM117B

Across TCGA cell cohorts, FAM117B mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM117B-associated genes across cancer lineages are CD532, IC-87114, and Nutlin-3a (-). Each is linked with FAM117B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM117B-to-partner and partner-to-FAM117B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD532 grouped by FAM117B-low versus FAM117B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM117B→partner) and Y-score (partner→FAM117B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD532 →	+0.501	+2.652	.012	.045	3	1
LARGE_INTESTINE	IC-87114 →	+0.249	+2.652	.015	.045	2	1
LARGE_INTESTINE	Nutlin-3a (-) →	+1.273	+2.646	<.001	.047	1	1
LARGE_INTESTINE	Niraparib →	+0.400	+2.646	.024	.047	1	1
LARGE_INTESTINE	FS112 →	+0.519	+2.786	.030	.037	1	1
LARGE_INTESTINE	Bleomycin (50 uM) →	+0.793	+2.722	.028	.040	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

CD532 by FAM117B expression — LARGE_INTESTINE

Explore this box plot interactively →