FAM117A

Across TCGA pan-cancer cohorts, FAM117A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FAM117A’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where FAM117A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FAM117A is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

PDAC, LSCC, and LUAD are the cancer types where FAM117A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM117A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	−0.573	<.001	7	view →
LSCC	Female	All	−0.341	<.001	7	view →
LUAD	All	All	−0.240	<.001	5	view →
HNSC	Male	II,III,IV	−0.407	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FAM117A–PDAC

Open the PDAC breakdown →