FAM114A2

Across TCGA patient cohorts, FAM114A2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM114A2-associated genes across cancer lineages are Rictor_pT1135, S6, and Caspase-7-cleavedD198. Each is linked with FAM114A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM114A2-to-partner and partner-to-FAM114A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by FAM114A2-low versus FAM114A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM114A2→partner) and Y-score (partner→FAM114A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.088	-1.807	.037	.027	3	2
UCEC	S6 →	+0.266	+2.999	.015	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.724	+2.604	.003	.005	3	2
UCEC	EGFR →	-0.150	-3.169	.023	.019	3	1
UCEC	Fibronectin →	-0.317	-2.797	.019	.003	3	1
UCEC	Notch1 →	+0.143	+2.183	.013	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Rictor_pT1135 by FAM114A2 expression — UCEC

Explore this box plot interactively →