FAM111B

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, FAM111B mutation is significantly associated with the RNA expression of many other genes, with 4,025 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM111B-associated genes across cancer lineages are FKBP4P2, PRM3, and OR6C2. Each is linked with FAM111B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM111B-to-partner and partner-to-FAM111B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM111B→partner) and Y-score (partner→FAM111B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCFKBP4P2 →+0.044+5.306<.001.00632
SKCMPRM3 →+0.124+4.180.004.00132
SKCMOR6C2 →+0.196+3.578<.001.00732
SKCMCRYGFP →+0.052+4.199<.001.00932
SARCRNA5SP386 →+0.437+5.477<.001.00432
BRCARNA5SP113 →+0.244+5.126<.001.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,025 associations by consensus.

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