Across TCGA patient cohorts, FAM111B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM111B-associated genes across cancer lineages are eIF4E, Ku80, and PCNA. Each is linked with FAM111B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM111B-to-partner and partner-to-FAM111B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM111B→partner) and Y-score (partner→FAM111B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.198	+2.820	.002	.001	3	2
UCEC	Ku80 →	+0.154	+1.276	.033	.012	3	2
UCEC	PCNA →	+0.207	+1.700	.001	.001	3	2
UCEC	Annexin-1 →	+0.487	+1.867	.002	.004	3	2
UCEC	ASNS →	+0.472	+1.999	<.001	.008	3	2
UCEC	4E-BP1 →	+0.368	+1.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

FAM111B survival (RNA) · tumor vs normal (RNA) · all FAM111B data types