Across TCGA cell cohorts, FAM111B mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM111B-associated genes across cancer lineages are KRTAP4-2, PRSS54, and MAGEB4. Each is linked with FAM111B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM111B-to-partner and partner-to-FAM111B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM111B→partner) and Y-score (partner→FAM111B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRTAP4-2 →	+0.028	+5.196	<.001	.005	3	1
BLOOD_Lymphoma	PRSS54 →	+0.043	+4.867	.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	PPP1R1A →	+0.316	+3.064	.001	.009	3	1
LARGE_INTESTINE	NR4A2 →	+0.828	+3.064	.003	.009	3	1
LARGE_INTESTINE	C8A →	+0.018	+2.777	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

FAM111B survival (RNA) · tumor vs normal (RNA) · all FAM111B data types