Across TCGA pan-cancer cohorts, FAM110D mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FAM110D’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FAM110D mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FAM110D is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where FAM110D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM110D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.602	<.001	10	view →
LUAD	Female	II,III,IV	−0.939	<.001	9	view →
LSCC	All	All	−0.376	.003	4	view →
HNSC	All	All	+0.327	.012	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: FAM110D RNA expression & survival · all FAM110D data types