Across TCGA pan-cancer cohorts, FAM110C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FAM110C data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM110C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM110C expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where FAM110C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.904	0.334	.008	32	view →
HNSC	OS	Tertile	III,IV	0.556	0.840	.002	14	view →
CCRCC	OS	Median	All	0.845	1.000	.003	12	view →
PDAC	OS	Median	All	0.248	0.648	.011	10	view →
LUAD	OS	Median	All	1.000	0.743	.022	2	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.810	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: FAM110C tumor-vs-normal RNA expression · all FAM110C data types