FAM110B

Across TCGA patient cohorts, FAM110B mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM110B-associated genes across cancer lineages are NF-kB-p65_pS536, Caspase-7-cleavedD198, and PRDX1. Each is linked with FAM110B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM110B-to-partner and partner-to-FAM110B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF-kB-p65_pS536 grouped by FAM110B-low versus FAM110B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM110B→partner) and Y-score (partner→FAM110B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF-kB-p65_pS536 →	-0.299	-2.000	.034	.029	3	3
COAD	Caspase-7-cleavedD198 →	+1.024	+2.423	<.001	.001	3	3
COAD	PRDX1 →	+0.172	+3.016	.001	.018	3	3
COAD	EGFR_pY1068 →	-0.355	-3.321	.002	.009	3	2
UCEC	eIF4E →	+0.210	+3.713	.001	<.001	3	2
COAD	GAPDH →	+0.478	+3.000	.009	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

NF-kB-p65_pS536 by FAM110B expression — UCEC

Explore this box plot interactively →