FAM110A

Across TCGA cell cohorts, FAM110A mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM110A-associated genes across cancer lineages are SMIM28, USP26, and DEFB131B. Each is linked with FAM110A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM110A-to-partner and partner-to-FAM110A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM28 grouped by FAM110A-low versus FAM110A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM110A→partner) and Y-score (partner→FAM110A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMIM28 →	+0.062	+5.228	<.001	.005	3	1
BLOOD_Lymphoma	USP26 →	+0.273	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	DEFB131B →	+1.010	+6.247	<.001	<.001	3	1
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	SLN →	+0.143	+3.334	.004	.008	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SMIM28 by FAM110A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →