FAM107A

Across TCGA pan-cancer cohorts, FAM107A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM107A data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher FAM107A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM107A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, KIRP, and LGG are the cancer types where FAM107A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.361	0.842	.004	18	view →
KIRP	OS	Median	All	0.157	0.704	.005	12	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.630	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FAM107A–OV (OS)

Open the OV breakdown →