FAM107A

Across TCGA patient cohorts, FAM107A mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM107A-associated genes across cancer lineages are C-Raf, A-Raf_pS299, and Heregulin. Each is linked with FAM107A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM107A-to-partner and partner-to-FAM107A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FAM107A-low versus FAM107A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM107A→partner) and Y-score (partner→FAM107A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.186	+2.321	.007	.034	3	2
UCEC	A-Raf_pS299 →	-0.211	-3.000	<.001	.036	3	1
UCEC	Heregulin →	-0.176	-2.321	.003	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.269	+2.472	.007	.011	3	1
UCEC	N-Ras →	-0.172	-2.973	.002	.035	3	1
UCEC	p27 →	+0.214	+3.169	.042	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

C-Raf by FAM107A expression — UCEC

Explore this box plot interactively →