FAM104A

Across TCGA pan-cancer cohorts, FAM104A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FAM104A data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FAM104A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM104A expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and HNSC are the cancer types where FAM104A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	1.000	0.860	.007	7	view →
UCEC	OS	Median	II,III,IV	1.000	0.620	.011	4	view →
HNSC	DFS	Median	II,III,IV	0.715	0.536	.032	3	view →
PDAC	OS	Median	All	0.515	0.266	.011	2	view →
CCRCC	DFS	Median	All	1.000	0.712	.045	2	view →
GBM	OS	Median	All	0.542	0.961	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FAM104A–LSCC (DFS)

Open the LSCC breakdown →