FAM104A

Across TCGA pan-cancer cohorts, FAM104A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FAM104A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where FAM104A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAM104A is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

CCRCC, HNSC, and LUAD are the cancer types where FAM104A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM104A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	III,IV	+0.570	<.001	11	view →
HNSC	Female	All	−0.388	.022	3	view →
LUAD	Female	All	−0.269	<.001	3	view →
LSCC	All	All	+0.143	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FAM104A–CCRCC

Open the CCRCC breakdown →