FAM104A

Across TCGA patient cohorts, FAM104A mutation is significantly associated with the RNA expression of many other genes, with 2,539 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM104A-associated genes across cancer lineages are RNU7-127P, RPL31P16, and SNURFL. Each is linked with FAM104A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM104A-to-partner and partner-to-FAM104A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-127P grouped by FAM104A-low versus FAM104A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM104A→partner) and Y-score (partner→FAM104A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU7-127P →	+0.567	+5.792	<.001	.003	3	2
UCEC	RPL31P16 →	+0.160	+2.061	.007	.008	3	2
CESC	SNURFL →	+0.182	+5.669	<.001	.003	3	1
CESC	DEFB123 →	+0.139	+5.010	<.001	.009	3	1
CESC	OR5T2 →	+0.066	+7.164	<.001	<.001	3	1
CESC	HAPLN4 →	+0.018	+5.539	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,539 associations by consensus.

RNU7-127P by FAM104A expression — LUSC

Explore this box plot interactively →