FAM104A

Across TCGA patient cohorts, FAM104A mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM104A-associated genes across cancer lineages are FOXO3a, Caspase-8, and Cyclin-B1. Each is linked with FAM104A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM104A-to-partner and partner-to-FAM104A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by FAM104A-low versus FAM104A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM104A→partner) and Y-score (partner→FAM104A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.106	-2.446	.031	.020	3	1
UCEC	Caspase-8 →	-0.331	-3.432	.006	.005	3	1
UCEC	Cyclin-B1 →	+0.714	+2.459	.008	.020	3	1
UCEC	Di-Ras3 →	-0.206	-2.459	.004	.020	3	1
UCEC	p62 Lck ligand →	+0.507	+2.817	.001	.036	2	1
UCEC	Shc_pY317 →	-0.202	-3.169	.005	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a by FAM104A expression — UCEC

Explore this box plot interactively →