FAM102B

Across TCGA pan-cancer cohorts, FAM102B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM102B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM102B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FAM102B is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where FAM102B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM102B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.509	<.001	8	view →
PDAC	Male	All	+0.538	<.001	6	view →
LSCC	Male	II,III,IV	−0.236	<.001	6	view →
CCRCC	All	All	+0.185	.014	4	view →
OV	All	All	−0.925	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FAM102B–HNSC

Open the HNSC breakdown →