FAM102B

Across TCGA patient cohorts, FAM102B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM102B-associated genes across cancer lineages are Ku80, LKB1, and Notch1. Each is linked with FAM102B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM102B-to-partner and partner-to-FAM102B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by FAM102B-low versus FAM102B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM102B→partner) and Y-score (partner→FAM102B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.227	+2.013	.032	.018	3	1
UCEC	LKB1 →	-0.099	-3.000	.039	.036	3	1
UCEC	Notch1 →	+0.146	+3.807	.021	<.001	3	1
UCEC	p62 Lck ligand →	+0.390	+3.469	.007	.002	3	1
UCEC	Annexin-1 →	+0.558	+3.189	.018	.010	3	1
UCEC	STAT3_pY705 →	-0.243	-2.000	.040	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Ku80 by FAM102B expression — UCEC

Explore this box plot interactively →