FAIM

Across TCGA patient cohorts, FAIM mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAIM-associated genes across cancer lineages are mTOR_pS2448, ATM, and FOXO3a_pS318_S321. Each is linked with FAIM in more than 1 cancer types. Because this analysis shows association rather than direction, both FAIM-to-partner and partner-to-FAIM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by FAIM-low versus FAIM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAIM→partner) and Y-score (partner→FAIM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.150	-2.986	.014	.035	3	2
UCEC	ATM →	-0.671	-2.584	<.001	.010	3	2
UCEC	FOXO3a_pS318_S321 →	-0.130	-2.105	.011	.017	3	1
UCEC	JNK_pT183_Y185 →	-0.173	-1.794	.013	.027	3	1
UCEC	JNK2 →	+0.177	+2.331	.031	.019	3	1
UCEC	Ku80 →	+0.246	+2.335	.011	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

mTOR_pS2448 by FAIM expression — UCEC

Explore this box plot interactively →