FAH

Across TCGA patient cohorts, FAH mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAH-associated genes across cancer lineages are GAPDH, ERK2, and MEK1. Each is linked with FAH in more than 1 cancer types. Because this analysis shows association rather than direction, both FAH-to-partner and partner-to-FAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by FAH-low versus FAH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAH→partner) and Y-score (partner→FAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.699	+2.820	.012	.035	3	2
UCEC	ERK2 →	+0.193	+3.321	.009	.009	3	2
UCEC	MEK1 →	+0.281	+3.169	.045	.018	3	2
UCEC	Shc_pY317 →	-0.126	-1.678	.031	.023	3	2
UCEC	EGFR_pY1068 →	-0.239	-2.222	.013	.010	3	1
UCEC	FoxM1 →	+0.247	+2.584	.012	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GAPDH by FAH expression — COAD

Explore this box plot interactively →