FAH

Across TCGA cell cohorts, FAH RNA expression is significantly associated with the go_rna of many other GO terms, with 5,830 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FAH-associated GO terms across cancer lineages are L-tyrosine catabolic process, Tyrosine metabolic process, and Phenol-containing compound catabolic process. Each is linked with FAH in more than 18 cancer types. Because this analysis shows association rather than direction, both FAH-to-partner and partner-to-FAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-tyrosine catabolic process grouped by FAH-low versus FAH-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAH→partner) and Y-score (partner→FAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	L-tyrosine catabolic process →	+1.346	+2.217	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Tyrosine metabolic process →	+0.338	+1.429	<.001	<.001	3	16
LUNG_SCLC	Phenol-containing compound catabolic process →	+0.222	+2.080	<.001	<.001	3	14
URINARY_TRACT	L-phenylalanine catabolic process →	+0.763	+1.669	.005	<.001	3	14
BONE	Chaperone-mediated autophagy →	+0.200	+1.793	<.001	<.001	3	11
URINARY_TRACT	L-phenylalanine metabolic process →	+0.308	+1.495	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,830 associations by consensus.

L-tyrosine catabolic process by FAH expression — LUNG_SCLC

Explore this box plot interactively →