FAF2

Across TCGA pan-cancer cohorts, FAF2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAF2 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAF2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAF2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where FAF2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.737	0.494	.004	46	view →
PDAC	OS	Quartile	II,III,IV	0.385	0.714	.007	36	view →
LSCC	OS	Quartile	All	0.644	0.955	.001	26	view →
CCRCC	DFS	Median	All	0.703	0.901	.004	18	view →
LUAD	DFS	Quartile	All	0.881	0.470	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAF2–HNSC (DFS)

Open the HNSC breakdown →